Abstract: Objective · To estimate correlation between coronary artery calcification score (CaCS) and prognosis of peritoneal dialysis (PD) patients.  Methods · The clinically stable patients who had undergone PD for at least 2 months were recruited for this prospective and observational cohort study. Coronary artery calcification was assessed by multislice spiral computed tomography and was recorded according to the Agatston score. The patients were assigned to 3 groups, i.e. no calcification group (CaCS=0), low calcification group (0<CaCS<400) and high calcification group (CaCS ≥ 400), to compare their basic data and endpoint events (including all-cause mortality, cardiovascular events and cardiovascular mortality). And then the correlation between CaCS and endpoint events was analyzed.  Results · A total of 254 PD patients (including 132 males) with a mean age of (62.9±15.0) years were recruited for this study. There were 93, 105, and 56 cases in no calcification group, low calcification group and high calcification group, respectively. Compared with no calcification group, patients with higher CaCS were older, had lower diastolic blood pressure, residual renal function, and serum albumin, and had higher glycosylated hemoglobin and serum insulin. Multivariate Cox regression revealed that CaCS was an independent risk factor for all the three endpoint events in PD patients.  Conclusion · CaCS was an independent predictor of all-cause mortality, cardiovascular events and cardiovascular mortality in PD patients.

Key words: coronary artery calcification score, peritoneal dialysis, prognosis, cardiovascular event, risk factor