›› 2018, Vol. 38 ›› Issue (5): 578-.doi: 10.3969/j.issn.1674-8115.2018.05.020

• Review • Previous Articles     Next Articles

Recent advances in the antitumor effects of evodiamine

XU Jun-jie1, YANG Ran1, YANG Fang-jing1, JIAO Xin1, LIU Ying-bin2   

  1. 1. Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2. Department of General Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2018-05-28 Published:2018-05-28
  • Supported by:
    National Natural Science Foundation of China, 81272402; The 10th Undergraduate Training Program for Innovation of Shanghai Jiao Tong University School of Medicine, 2016089

Abstract: Evodiamine is the natural component extracted Euodiae Fructus. Recently, growing evidence has proved that evodiamine has great effects on suppressing cell viability and proliferation, arresting cell cycle, inducing apoptosis, promoting autophagy, inhibiting the formation of microvascular angiogenesis as well as affecting epigenetic modification in cancer. Recent studies have continuously revealed related signal pathways involved in evodiamine such as PI3K-Akt and JAK-STAT pathways, as well as the impact of evodiamine on survivin, vascular endothelial growth factor and miRNAs. With the development and synthesis of evodiamine derivatives and related herbal formulations, the understanding of antitumor activity of evodiamine is gradually deepening. The important clinical significance and market value of evodiamine can be prospected.

Key words: evodiamine, antitumor activity, mechanism, derivative, combined medication

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