Abstract: Antipsychotic drugs are the most commonly used treatment for schizophrenia. How antipsychotics affect brain function so as to improve clinical symptoms is still poorly understood. How brain works at rest reflects the inherent activity pattern of the brain in the resting state which is a foundation of all cognitive activities. To learn how antipsychotics affect brain function is helpful to understand the pathogenesis of mental illness and to seek better therapeutic targets. In this article, the changes of resting state brain area activities, brain network functional connectivities and the topology characteristics of whole brain functional network in the patients with schizophrenia before and after antipsychotic treatment are reviewed, and the future prospect is discussed.

Key words: antipsychotics drug, resting state, brain network, dynamic functional connectivity