JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (11): 1519-1523.doi: 10.3969/j.issn.1674-8115.2020.11.015

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Research progress in the mechanism of ferroptosis and its role in liver related diseases

HE Ming, WEI Qian, ZHANG Ying-ting   

  1. Key Laboratory for Cell Differentiation and Apoptosis, Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University College of Basic Medical Sciences, Shanghai 200025, China
  • Online:2020-11-28 Published:2021-01-13
  • Supported by:
    Natural Science Foundation of Shanghai (19ZR1428400); National Natural Science Foundation of China (82070603, 81470841, 92057118); Innovative Research Team of High-Level Local Universities in Shanghai (SSMU-ZDCX20180800); Supported by Youth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine (JYKCGZS15).

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Abstract: Ferroptosis is a type of cell death caused by iron-dependent lipid peroxidation. Glutathione peroxidase 4 (GPX4) can prevent ferroptosis by converting lipid peroxides into nontoxic lipid alcohols under normal condition. However, recent studies have shown that ferroptosis in hepatocytes is one of the factors that induce and aggravate various liver diseases such as alcoholic fatty liver disease. Thereby, inducing ferroptosis of cancer cells by inhibiting GPX4 may be a new strategy for the treatment of liver cancer. This article reviews the molecular mechanism of ferroptosis and its role in liver related diseases, in order to provide new research directions and ideas for the treatment of liver diseases.

Key words: ferroptosis, liver disease, lipid peroxidation, glutathione peroxidase 4 (GPX4), liver cancer

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