JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (12): 1683-1686.doi: 10.3969/j.issn.1674-8115.2020.12.021

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An update on the cell origin of retinoblastoma

SHI Han-han, WANG Shao-yun, JIA Ren-bing   

  1. Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai 200011, China
  • Online:2020-12-28 Published:2021-02-02
  • Supported by:
    Shanghai Science and Technology Committee Project (17DZ2260100, 19JC1410200); Innovative Research Team of High-Level Local Universities in Shanghai.

Abstract: Retinoblastoma is the malignant intraocular tumor most commonly happened on children, especially the children under 3 years old. It may lead to blindness, eyeball removal and even death, which severely threaten the safety and quality of children’s life. Exploring the origin of tumor cells is conducive to the reveal of the pathogenesis as well as the guidance on diagnosis, classification and treatment of retinoblastoma. Based on the studies on retinal development, three theories regarding the cell origin of retinoblastoma, namely the origin of retinal precursor cells, the origin of cone cells and the origin of horizontal cells or Müller glia cells have lately been proposed. This article reviews and summarizes the research of the origin cells in retinoblastoma.

Key words: retinoblastoma, the origin of retinal precursor cells, the origin of cone cells, the origin of horizontal cells or Müller glia cells

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