›› 2018, Vol. 38 ›› Issue (6): 699-.doi: 10.3969/j.issn.1674-8115.2018.06.021

• Review • Previous Articles     Next Articles

Roles of long non-coding RNA in intraocular malignant tumor and its mechanisms

FU Xiao1, HUANG Rui1, FAN Xian-qun2, ZHANG He2   

  1. 1. Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2. Department of Ophthalmology, Shanghai Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Online:2018-06-28 Published:2018-07-03
  • Supported by:
    National Natural Science Foundation of China, 31470157; Fund for Key Laboratory of Shanghai, 17DZ2260100

Abstract: Retinoblastoma (RB) is the most common intraocular malignant tumor in early childhood, which has an adverse effect not only on the eyesight, but also on patients’ life. Uveal melanoma (UM) is an another common intraocular malignant tumor in adults, nearly half of the patients will have metastasis of tumor with a low survival rate. The long non-coding RNAs (lncRNAs) are non-coding RNA with a length greater than 200 nt. More and more studies have confirmed that lncRNAs are involved in the proliferation, migration and invasion of tumorsregulating the gene at various levels, which makes lncRNAs become the novel target in the therapy of intraocular malignant tumors. This article reviewed studies of the roles and mechanisms of lncRNAs in RB and UM.

Key words: long non-coding RNA, retinoblastoma, uveal melanoma, mechanism

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