›› 2019, Vol. 39 ›› Issue (2): 198-.doi: 10.3969/j.issn.1674-8115.2019.02.017

• Review • Previous Articles     Next Articles

Research progress on the role of long non-coding RNAs in central nervous system and schizophrenia

FANG Yu, WANG Wei-di, CHENG Ying, CUI Dong-hong   

  1. Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2019-02-28 Published:2019-03-19
  • Supported by:
    National Key Research and Development Program, 2017YFC0909200; National Natural Science Foundation of China, 81671336; Shanghai Committee of Science and Technology Research Project, 13dz2260500

Abstract: Schizophrenia is a complex and severe psychiatric disorder with an estimated heritability of around 80%, but the exact nature and function of genetic components, and genetic mechanisms have not yet been revealed. Long non-coding RNAs (lncRNAs) are a type of non-coding RNAs which are widely expressed in the central nervous system. They regulate gene transcription in various ways, and participate in neural stem cell proliferation and differentiation, and synaptic plasticity. In recent years, many studies have reported that lncRNAs were abnormally expressed in patients with schizophrenia and momodels, which played an important role in this disorder. This review described the biological characteristics and gene regulation mechanisms of lncRNAs, and the role of lncRNAs in the central nervous system and the pathogenesis of schizophrenia.

Key words: long non-coding RNA (lncRNA), central nervous system, schizophrenia, Gomafu, disrupted in schizophrenia 2 (DISC2), embryonic ventral forebrain-2 (EVF-2)

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