JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (5): 665-670.doi: 10.3969/j.issn.1674-8115.2021.05.018

• Review • Previous Articles     Next Articles

Relationship between non-coding RNAs and vascular diseases of diabetes mellitus

Shu-jun WAN(), Xiang KONG, Kun LÜ()   

  1. Key Laboratory of Non-coding RNA Transformation Research of Anhui Higher Education Institution, Wannan Medical College, Wuhu 241001, China;Central Laboratory of Yijishan Hospital, Wannan Medical College, Wuhu 241001, China
  • Online:2021-05-28 Published:2021-05-27
  • Contact: Kun Lü;
  • Supported by:
    National Natural Science Foundation of China(81472017)


Non-coding RNAs (ncRNAs) are a class of molecules that do not encode protein. As important biological regulatory factors, they can affect the occurrence and development of vascular diseases of diabetes mellitus (DM) at the levels of transcription and post-transcription. ncRNAs mainly include microRNAs (miRNAs), long non coding RNAs (lncRNAs) and circular RNAs (circRNAs) according to their fragment sizes. miRNAs can regulate target gene expressions at the post-transcriptional level and have the potential to be their clinical markers. lncRNAs affect a variety of molecular signaling pathways. The role of lncRNAs in vascular diseases of DM has attracted increasing attention in recent years. circRNAs possess significant capabilities of gene regulation and could participate in pathological process of DM by competing with miRNAs for binding sites. To develop new ideas for the diagnosis and treatment of vascular diseases of DM, a brief review of the current research on ncRNAs and DM angiopathy is provided.

Key words: non-coding RNA (ncRNA), microRNA (miRNA), long non-coding RNA (lncRNA), diabetes mellitus (DM), vascular diseases of diabetes mellitus

CLC Number: