›› 2018, Vol. 38 ›› Issue (6): 704-.doi: 10.3969/j.issn.1674-8115.2018.06.022

• Review • Previous Articles     Next Articles

Relationship between the APOE genotypes and the common major psychosis

YU Xiao-yan1, 2, LI-Xia1   

  1. 1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Shanghai Changning District Mental Health Center, Shanghai 200335, China
  • Online:2018-06-28 Published:2018-07-03
  • Supported by:
    National Natural Science Foundation of China,81671402; Guiding Medical Project of Shanghai Science and Technology Committee, 15411961400

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Abstract: Apolipoprotein E (APOE) is a lipid transfer protein, which plays an important role in maintaining the stabilization of nerve and recovering. Alzheimers disease (AD) is a neurodegenerative disorder. Most studies showed that APOE genotypes were closely related with AD. In clinical practice, AD is mainly manifested as progressive cognitive decline, and often accompaniedmental behavioral symptoms. These symptoms also exist in common severe mental illness. It is worth thinking about the correlation between APOE genotypes and these diseases. This article reviewed the relationship between the APOE genotypes and the common major psychosis.

Key words: apolipoprotein E, genotype, Alzheimers disease, major psychosis

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