›› 2017, Vol. 37 ›› Issue (7): 1033-.doi: 10.3969/j.issn.1674-8115.2017.07.027

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Advances in differences between ApoE -/- and LDLR -/- atherosclerotic model mice#br#

WANG Jian-ru, LIU Ping   

  1. Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
  • Online:2017-07-28 Published:2017-08-25
  • Supported by:
    National Natural Science Foundation of China, 81573739; Scientific Research Project of Science and Technology Committee of Shanghai Municipality, 17140901002; Doctoral Scientific Fund of the Ministry of Education, China, 20133107110003

Abstract: Animal models are very important tools to study the pathogenesis, pathology and treatment of atherosclerosis. Animal models for studying atherosclerosis include rodents, rabbits, pigs and nonhuman primates. Among them, ApoE -/- mouse and LDLR-/- mouse are currently the most widely used. They can form atherosclerotic lesions, but in some respects there are significant differences. In this paper, the differences between the two model mice in lipid metabolism, plaque formation and pathology, lymphocytes, macrophages, dendritic cells, microRNA expression and regulation were reviewed.

Key words: atherosclerosis, animal model, apolipoprotein E, low density lipoprotein receptor, gene knockout