JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (07): 901-907.doi: 10.3969/j.issn.1674-8115.2020.07.007

• Original article (Clinical research) • Previous Articles     Next Articles

Predictive value of dynamic contrast-enhanced MRI of original plaque on carotid artery in-stent restenosis

GE Xiao-qian1, LI Xiao2, ZHAO Hui-lin2, SUN Bei-bei2, XU Jian-rong2, LIU Xiao-sheng2   

  1. 1. Department of Medical Imaging, Shandong Provincial Western Hospital, Jinan 250022, China; 2. Department of Radiology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2020-07-28 Published:2020-09-23
  • Supported by:
    National Natural Science Foundation of China (81801650, 81571630); Shanghai Municipal Health Commission (201940060); Renji Southern Hospital PHD Program (2019NYBSZX01).

Abstract: Objective · To explore the value of dynamic contrast-enhanced MR imaging (DCE-MRI) of original plaque to predict carotid artery in-stent restenosis (ISR). Methods · Forty cases of the patients with carotid atherosclerosis who were to undergo the carotid artery stenting (CAS) were included in this study. All participants underwent vessel wall MR imaging (VW-MRI) and DCE-MRI within one week before CAS. Carotid digital subtraction angiography (DSA) were performed at the sixth month to reassess the stenosis of stent. The correlation between DCE-MRI and ISR was evaluated. Results · The level of Ktran in ISR group was significantly higher than that in non-ISR group (P=0.000), and so was the vP (P=0.037). Ktrans could independently predict ISR (OR=1.43, 95%CI 1.17-1.56, P=0.012), and the cut-off value of Ktrans was 0.09 min-1 (sensitivity=100%, specificity=87.5%). Conclusion · Intraplaque inflammation may lead to excessive intimal hyperplasia after ISR. Ktrans could be a risk predictor of ISR with high sensitivity and specificity. DCE-MRI could be an effective tool to predict ISR.

Key words: dynamic contrast-enhanced MR imaging (DCE-MRI), carotid artery, atherosclerosis, in-stent restenosis

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