›› 2017, Vol. 37 ›› Issue (6): 836-.doi: 10.3969/j.issn.1674-8115.2017.06.021

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Clinical research progress in immunotherapy against atherosclerosis

YOU Sha-sha, CAO Hui-min, XUE Xiao-mei, HE Bin   

  1. Department of Anesthesiology and SICU, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2017-06-28 Published:2017-07-05
  • Supported by:

    National Natural Science Foundation of China, 81470390; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152218)


 Atherosclerosis is a chronic inflammatory disease, with both the innate and adaptive immune systems responding to many endogenous and exogenous antigens. Subsequent investigations have revealed that an immunomodulatory strategy via active immunization against atherosclerotic plaque antigen(s) could potentially alleviate atherosclerosis. Substantial data from clinical investigations support the key role of immune system in atherosclerosis. So, it may be promising to develop immunotherapy against atherosclerosis. The paper reviews current status of immunization studies and possible associated immunemediated inflammatory mechanisms in atherosclerosis.

Key words: atherosclerosis, passive immunization;, vaccine, low-density lipoprotein