›› 2017, Vol. 37 ›› Issue (6): 842-.doi: 10.3969/j.issn.1674-8115.2017.06.022

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Research progress of effect and mechanism of protein arginine methyltransferase in tumors

WEN Jun, MIN Xue-jie, ZHAO Li, ZHAO Xiao-ping   

  1. Department of Nuclear Medicine, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2017-06-28 Published:2017-07-05
  • Supported by:

    National Natural Science Foundation of China, 81372195, 81572719; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152516

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Abstract:

 Protein arginine methyltransferase (PRMT) can methylate a variety of proteins, including histones and non-histones, affecting a variety of cellular processes such as transcription, RNA splicing, DNA repair, and cell cycle control. The activity of PRMT is affected by a variety of regulatory mechanisms, and its abnormal expression plays an important role in the development of the diseases, especially in tumors such as breast cancer and leukemia. PRMT has a unique value in the diagnosis or treatment of tumors. With the further exploration of PRMT methylation mechanism, PRMT selective inhibitors have made some progress. PRMT-specific inhibitors are expected to be targeted drugs for the treatment of tumors.

Key words: PRMT, methylation, tumor