›› 2018, Vol. 38 ›› Issue (1): 108-.doi: 10.3969/j.issn.1674-8115.2018.01.021

• Review • Previous Articles     Next Articles

Vaccine strategies in prevention and treatment of atherosclerosis#br#

XUE Yu-chen, YOU Sha-sha, CAO Hui-min, HE Bin   

  1. Department of Anesthesiology and SICU, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2018-01-28 Published:2018-03-09
  • Supported by:
     National Natural Science Foundation of China, 81470390; Shanghai Municipal  Education Commission—Gaofeng Clinical Medicine Grant Support, 20152218; Clinical Research Plan of Shanghai Hospital Development Center, 16CR3006A; Program of  Science and Technology Commission of Shanghai Municipality, 17411954700

Abstract: Atherosclerosis is an immune-mediated inflammatory disease of the arterial wall, with both the innate and adaptive immune systems responding  to many endogenous and exogenous antigens. Both proatherogenic as well as atheroprotective roles have been identified for the immune system in  atherosclerosis. Hence, it is conceivable that an immuno-modulatory strategy via active immunization against many of these antigens could potentially alter the natural history of atherosclerosis. Cholesterol ester transfer protein (CETP) plays an important role in lipid metabolism, suggesting it might prevent  atherosclerosis. This review discusses the recent advances of vaccine targeting the development of atherosclerosis, mainly about the CETP targeting vaccines.

Key words: &ensp, atherosclerosis, &ensp, immunization, &ensp, vaccine, &ensp, cholesterol&ensp, ester&ensp, transfer&ensp, protein