›› 2018, Vol. 38 ›› Issue (1): 112-.doi: 10.3969/j.issn.1674-8115.2018.01.023

• Review • Previous Articles     Next Articles

Role of B lymphocytes in pathogenesis of neuromyelitis optica spectrum disorder#br#

HAN Lu1, LI Mei2, ZHU De-sheng1, LI Ze-zhi1, LIU Ming-yuan2, GUAN Yang-tai1   

  1. 1. Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, China; 2. Department of Neurology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
  • Online:2018-01-28 Published:2018-03-09
  • Supported by:
     National Natural Science Foundations of China, 81200924, 81230027, 81401127; Foundation of Shanghai Municipal Commission of Health and Family  Planning, 201440347, 20134Y044; Shanghai Jiao Tong University Medicine-Engineering Foundation, YG2016MS48

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Abstract:  The neuromyelitis optica spectrum disorders (NMOSD) are a spectrum of central nervous system autoimmune diseases caused by humoralmediated immunity. NMOSD is characterized by specific expression of aquaporin-4 (AQP-4) antibody and involvement of optic nerve and spinal cord.  However, the expression level of AQP-4 antibody is not directly proportional to disease activity and recurrence rate, suggesting that multiple mechanisms  have been involved in mediating the process of disease. Many evidences of clinical and basic experiments indicated that B lymphocytes play an important  role in the pathogenesis of NMOSD. This paper mainly summarized the role of B lymphocytes in the pathogenesis of NMOSD, including aspects of antigen presentation, humoral immunity, regulatory B cell effect and B cell immune tolerance.

Key words: neuromyelitis&ensp, optica&ensp, spectrum&ensp, disorder, &ensp, B&ensp, lymphocytes, &ensp, pathogenesis