• Original article (Clinical research) • Previous Articles     Next Articles

Association of carotid wall shear rate with carotid reconstruction in kidney transplant recipients

LI Zhao-jun1, LI Fan1, QIN Yan2, ZHANG Qian3, DU Lian-fang1, LUO Xiang-hong3   

  1. 1.Department of Ultrasound, 2.Department of Urology, 3.Department of Echocardiography, Shanghai General Hospital , Shanghai Jiao Tong University, Shanghai 200080, China
  • Online:2017-01-28 Published:2017-01-19
  • Supported by:

    Foundation of Shanghai Municipal Commission of Health and Family Planning,201440290,201640043;Foundation of Science and Technology Committee of Shanghai Municipal,15411969100,16411969300;Interdisciplinary Projects of Medicine and Engineering from Shanghai Jiao Tong University,YG2015MS28


Objective · To analyze the relationships between the carotid structure and the shear rate (SR) in the patients with end-stage renal disease (ESRD) and the kidney transplant recipients(KTR), and to explore the effects of SR on the carotid structure. Methods · Thirty-one KTR, 31 patients with ESRD supported by hemodialysis and 84 control subjects were offered an ultrasound of carotid artery. Both sides of carotid intima-media thickness (CIMT), common carotid arterial diameter (CCAD) and SR were measured and their relationships were analyzed. Results · ① Compared with KTR group and control group, ESRD group had significantly thicker CIMT and wider CCAD , but there was no significant difference between KTR group and control group. ② In the ESRD and KTR group, the SR was less than that in control group respectively. There was no significant difference in SR between ESRD and KTR group. ③ In all subjects, CIMT and CCAD were all negative relative with SR. Moreover, in subgroups analysis, CIMT and CCAD were negative linear relative with SR in three groups respectively. Conclusion · The carotid artery was reconstructed in ESRD group, but was improved after successful kidney transplantation. The SR played a vital role in this alteration.

Key words:  kidney transplantation, end-stage renal disease, carotid artery, reconstruction, shear rate