JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (5): 690-694.doi: 10.3969/j.issn.1674-8115.2021.05.022

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Research progress in animal model of acute lung injury

Jing-yi FU(), Lei WANG, Yi YANG()   

  1. Department of Thoracic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233, China
  • Online:2021-05-28 Published:2021-05-27
  • Contact: Yi YANG;


Acute lung injury (ALI) refers to the occurrence of hypoxic respiratory failure and even acute respiratory distress syndrome caused by various factors. The morbidity and fatality rate of ALI are very high, but the research on its pathogenesis and treatment methods has not made much progress. Therefore, it is very necessary to establish animal models to simulate acute lung injury. In this paper, the literature on animal models of ALI in recent years is collected and summarized, and the selection of animal models of acute lung injury and the evaluation methods of lung injury are reviewed, so as to provide reference for the establishment of animal models of ALI.

Key words: acute lung injury (ALI), animal model, animal experiment

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