›› 2017, Vol. 37 ›› Issue (9): 1292-.doi: 10.3969/j.issn.1674-8115.2017.09.018

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Application and development of genetic knockout animal models in researches of obsessive-compulsive disorder#br#

WANG Pei, XU Ting-ting, ZHAO Qing, WANG Zhen   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2017-09-28 Published:2017-10-10
  • Supported by:
     National Natural Science Foundation of China, 81671340; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support, 20161321

Abstract: Recently, some progress has been made in the clinical study of obsessive compulsive disorder (OCD). Human research has inherent limitation because of its non-invasive nature, while animal models can break through the shortcomings of human research, allowing us to more accurately study the pathophysiology of OCD. Therefore, many researchers tried to use genetic knockout animal models to further study the etiology of OCD. In this review, recent progress about this kind of research was reviewed. [

Key words: obsessive-compulsive disorder, animal model, gene knockout