Advances in cell wall structure and Candida albicans-host interaction

doi:10.3969/j.issn.1674-8115.2021.09.017

Abstract

Abstract:

Candida albicans is an opportunistic human fungal pathogen. The mortality rate of blood infection caused by Candida albicans is as high as 40% while that of the cancer patients can even reach to 70%, which greatly increases the burden of human health. The cell wall of Candida albicans is the frontline of defense against external stress and the first contact point between fungi and host. Therefore, the cell wall is very important for fungi-host interaction and immune recognition, and is the most attractive target for antifungal therapy. Once the balance of synthesis and remodeling of cell wall of Candida albicans is broken, the molecular integrity of cell wall will be disturbed, which will finally lead to cell lysis and death. This paper reviews the characteristics of cell wall components of Candida albicans and their functions on fungi-host interaction and immune recognition mechanism, in order to provide novel research clues and theoretical basis for identification of specific antifungal targets and development of more economic and effective antifungal drugs.

Key words: Candida albicans, cell wall, fungi-host interaction, immune recognition, antifungal agent

CLC Number:

R379.4

Yi-kun MEI, Jing-cong TAN, An-jun WANG, Hui WANG, Ning-ning LIU. Advances in cell wall structure and Candida albicans-host interaction[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(9): 1246-1251.

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