Research progress of chaperone-mediated autophagy in Alzheimer's disease

doi:10.3969/j.issn.1674-8115.2021.11.020

Abstract

Abstract:

Alzheimer's disease (AD) is a common neurodegenerative disease. Its main pathological change is senile plaque (SP) formed by massive accumulation of amyloid β-protein (Aβ) and neurofibrillary tangles (NFTs) formed by excessive phosphorylation and accumulation of Tau protein in cells. Chaperone-mediated autophagy (CMA) selectively transfers proteins with CMA motifs to lysosomes for degradation. When the autophagy process is impaired, Aβ and abnormal phosphorylated Tau protein will accumulate in neurons, which can destroy the normal function of cells and accelerate their death. Relevant studies have shown that CMA is an important pathway for abnormal protein degradation in early AD, and the inactivation of this pathway may play an important role in the progression of AD. This paper reviews the concept, and physiological role of CMA and the pathological relationship between CMA and AD, and elaborates the role of inactivation of CMA pathway in AD diseases, in order to provide new ideas for the research and treatment of AD pathogenesis.

Key words: chaperone-mediated autophagy (CMA), Alzheimer's disease (AD), Tau protein, amyloid β-protein (Aβ)

CLC Number:

R741.02

Jun-hui CHEN, You-quan GU, Li-he YAO, Wei ZHANG, Huai-xiang WANG. Research progress of chaperone-mediated autophagy in Alzheimer's disease[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2021, 41(11): 1529-1534.

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