Research progress in the function of desmoglein-2 in digestive system tumors

doi:10.3969/j.issn.1674-8115.2022.02.018

Abstract

Abstract:

Desmoglein-2 (DSG2) is a member of the cadherin family. As an important part of desmoglein, DSG2 mainly plays a role in maintaining intercellular adhesion. Studies have found that DSG2 can also regulate cell proliferation, differentiation and apoptosis through signal transduction, and plays a key role in regulating intestinal epithelial barrier. With the deepening of research, more and more evidence shows that DSG2 is abnormally expressed in a variety of digestive system tumors, and the expression levels are different. The expression level is closely related to the prognosis of tumors. It is speculated that DSG2 plays different roles in the occurrence and development of different digestive system tumors. This article reviews the biological function of DSG2 and its role in digestive system tumors.

Key words: desmoglein-2 (DSG2), digestive system tumors, biological function

CLC Number:

R730.2

Yanqing LI, Xiaoxia WANG, Xiangdong JIA, Meng REN, Tianxiang XU. Research progress in the function of desmoglein-2 in digestive system tumors[J]. JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE), 2022, 42(2): 247-252.

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References 46

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