Recent researches show that calcium- and integrin-binding proteins (CIB) express in lots of tissues and participate in a wide variety of different cell biological processes. CIB can interact with multitudinous proteins, and may involve in the DNA damage response, cell cycle, cell apoptosis, embryogenesis, neuronal plasticity and neurodegenerative diseases. So in-depth research on CIB may provide new ideas for the treatment of diseases. The research progress of CIB is reviewed in this paper.