Research progress on the neuroinflammation mechanisms in bipolar disorder

doi:10.3969/j.issn.1674-8115.2025.01.013

Abstract

Abstract:

Bipolar disorder (BD) is a chronic, recurrent mental illness characterized by extreme fluctuations in mood and state, clinically manifested as recurrent or alternating manic, depressive, and mixed episodes. The pathogenesis is complex and remains unknown, with neuroinflammation considered as a key factor in its development. In-depth research not only helps to understand the etiology, but also provides direction for the development of new therapeutic targets. This paper reviews recent studies on neuroinflammation in BD, discusses changes in peripheral and central inflammation and associated biomarkers, explores the underlying mechanisms of pathogenesis, and briefly describes the mechanisms and potential of mood stabilizers and new therapeutic drugs in anti-inflammatory effect, aiming to suggest possible future research directions.

Key words: bipolar disorder, neuroglial cell, neuroinflammation, biomarker

CLC Number:

R749.4

WANG Xiaohong, FANG Yiru. Research progress on the neuroinflammation mechanisms in bipolar disorder[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(1): 107-112.

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References 40

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