›› 2010, Vol. 30 ›› Issue (1): 104-.

• Review • Previous Articles     Next Articles

Research advances in peroxisome proliferator activated receptor-gamma and renal fibrosis

LU Ying, reviewer；WANG Wei-ming, reviser   

  1. Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2010-01-26 Published:2010-01-26

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Abstract:

The end stage of chronic renal diseases is characterized by glomerular sclerosis and interstitial fibrosis. Studies have revealed that effective amelioration of renal fibrosis can significantly delay the progression of chronic renal diseases. Peroxisome proliferator activated receptors (PPARs) are ligand-activated nuclear transcriptional factors of the nuclear hormone receptor superfamily, and PPAR-γ is one of the phenotypes of PPARs. The effect of PPAR-γ on inhibiting renal fibrosis has become a hot spot. In this article the research advances of PPAR-γ in amelioration of renal fibrosis are reviewed.

Key words: peroxisome proliferator activated receptor-γ, chronic kidney disease, glomerular sclerosis, renal interstitial fibrosis