• Original article (Clinical research) • Previous Articles     Next Articles

Clinical study on inpatients with chronic kidney disease and hypertension

ZHU Min-xia1,2, NI Zhao-hui1,2, ZHANG Wei-ming1,2, MOU Shan1, WANG Qin1, GU Le-yi1, ZHOU Wen-yan1, CAI Hong1,2, CHE Xia-jing1, ZHANG Min-fang1, CAO Li-ou1, FANG Wei1, QIAN Jia-qi1   

  1. 1.Department of Nephrology, Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine, Shanghai 200112, China； 2.Department of Nephrology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2015-12-28 Published:2016-01-21
  • Supported by:

    National Natural Science Foundation of China， 81370794， 8157040263； Major Science and Technology Support Program of Ministry of Science and Technology in the National “12th 5-year Plan” of China， 2011BAI10B04， 2011BAI10B08

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Abstract:

Objective  To investigate the clinical characteristics of inpatients with chronic kidney disease (CKD) and hypertension. Methods  A cross-sectional and retrospective epidemiological study was carried out. The rates of incidence, awareness, treatment, and control of hypertension of inpatients with CKD admitted by the Department of Nephrology of Renji Hospital, Shanghai Jiao Tong University School of Medicine from November 2009 to February 2010 were surveyed and risk factors and the use of antihypertensive drugs were investigated. The control of hypertension and adverse events of patients with CKD and hypertension was surveyed by telephone from June to August 2015. Results  A total of 439 patients with CKD were enrolled. The rates of incidence, awareness, treatment, and control of hypertension were 69.5% (305/439), 95.4% (291/305), 92.8% (283/305), and 36.4% (111/305), respectively. 61.3% (187/305) of inpatients with CKD and hypertension were administrated with more than one antihypertensive drug. Follow-up after 5 years revealed that the rate of adverse events of patients with poor control of hypertension was significantly higher than that of patients with well control of hypertension (P<0.001). Conclusion  ①The rates of incidence, awareness, and treatment of hypertension of patients with CKD are high, while the rate of well control of hypertension is low. ②Most patients with CKD use more than one antihypertensive drug to control the blood pressure. ③Well control of hypertension can remarkably reduce the incidence of adverse events.

Key words: chronic kidney disease, hypertension, combination therapy of antihypertension, adverse events