›› 2010, Vol. 30 ›› Issue (5): 511-.

• Monographic report (Adrenal diseases) • Previous Articles     Next Articles

Aldosterone and resistant hypertension

ZHANG Xia, reviewer;WANG Wei-qing, reviser   

  1. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2010-05-25 Published:2010-05-28
  • Supported by:

    Shanghai Science and Technology Committee Foundation, 064119629

Abstract:

Resistant hypertension is defined as blood pressure that remains above goal despite the use of three different antihypertensive medications in effective doses, ideally including a diuretic. It is special and not rare in clinic. Aldosterone, the most important mineralocorticoid, is extensively involved in various metabolic activities. However, aldosterone excess plays an important role in the development of resistant hypertension.

Key words: aldosterone, resistant hypertension, mineralocorticoid receptor antagonist