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Value of angiotensin Ⅱ and aldosterone for the diagnosis of atrial fibrillation in patients with primary hypertension

ZHAO Li-qun1, LI Xu-guang1, XIE Li-jun1, WU Hai-qing1, WANG Zhi-min2, LIU Shao-wen1   

  1. 1. Department of Cardiology, Shanghai Genersl Hospital, Shanghai Jiao Tong University, Shanghai 200080, China;2. Department of Genetics, Chinese National Human Genome Center and Shanghai Industrial Technology Institute, Shanghai 201203, China

  • Online:2016-12-28 Published:2016-12-29
  • Supported by:

    National Natural Science Foundation-Outstanding Youth Foundation, 81300090

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Abstract:

Objective · To explore whether plasma angiotensin Ⅱ(AngⅡ) and aldosterone (ALD) in patients with primary hypertension can be used as biomarkers for the occurrence of atrial fibrillation and to guide the treatment of atrial fibrillation. Methods · 179 atrial fibrillation patients were enrolled and assigned to the train group (n=72) and the verification group (n=107) and 189 primary hypertensive patients were enrolled and assigned to the train group (n=75) and the verification group (n=114). Plasma renin activity (PRA), Ang Ⅱ, and ALD levels were measured using radioimmunity and compared between groups. The efficacy of Ang Ⅱand ALD on the diagnosis of atrial fibrillation was analyzed using ROC curves. Results · The atrial fibrillation group had higher Ang Ⅱand ALD levels than the hypertensive group (P=0.000). ROC curve analysis showed that sensitivity, specificity, and cut-off value were 0.92, 0.80, and 58.00 pg/mL for Ang Ⅱand 0.93, 0.96, and 150.00 pg/mL for ALD. The differences in AngⅡand ALD distributions between two groups were statistically significant (P =0.000). Conclusion · The plasma Ang Ⅱand ALD can be used as biomarkers for predicting atrial fibrillation in patients with primary hypertension and as an important index for using RAAS system blockers for the treatment of atrial fibrillation.

Key words: atrial fibrillation, essential hypertension, renin-angiotensin-aldosterone system