Abstract:

The migration of leukocytes mediated by chemokines is a basic mode in inflammatory reaction, and Duffy antigen receptor for chemokines (DARC) plays an important role in the balance and elimination of chemokines. Many researches have indicated that the changes of DARC expression on endothelial cells and erythrocytes are related to many human inflammatory diseases and infectious diseases. The structure, distribution and bionomics of DARC and the research progress on roles of DARC in the inflammation-related diseases are reviewed in this paper.

Key words: Duffy antigen receptor for chemokines, chemotactic factor, inflammatory reaction