Abstract:

With the increase of prevalence year by year, chronic kidney disease (CKD) has become one of the major diseases that threaten the public health all over the world. Adipose tissues are important resources of cytokines which cause metabolic disorder in CKD. These cytokines can promote inflammation, and lead to uremia-related insulin resistance, which may play an important role in the occurrence and development of CKD. Renin-angiotensin system blockade, which slows down the development of CKD by regulation of adipocyte dysfunction, is the classical drug in the treatment of CKD. The research progress of renin-angiotensin system blockade in the treatment of CKD is reviewed in this paper.

Key words: chronic kidney disease, rennin-angiotensin system, blockade, adipocytokines