›› 2011, Vol. 31 ›› Issue (4): 501-.doi: 10.3969/j.issn.1674-8115.2011.04.028

• Review • Previous Articles     Next Articles

Research progress of BMP-7 induced mesenchymal to epithelial transition in organ fibrosis

CHEN Li-li, GUO Can-jie, CHEN Yuan-wen, SHEN Feng, LI Ding-guo   

  1. Department of Gastroenterology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
  • Online:2011-04-28 Published:2011-04-28
  • Supported by:

    National Natural Science Foundation of China, 30971332


Fibrosis is a common result of chronic injury in many organs. Studies have revealed that epithelial to mesenchymal transition might be the underlying mechanism of fibrotic disorder. Transforming growth factor-β1 has been suggested to induce epithelial to mesenchymal transition and promote organ fibrosis. In contrast, bone morphogenetic protein-7 can block the effect of transforming growth factor-β and induce mesenchymal to epithelial transition which may be helpful to improve organ fibrosis. However, the molecular mechanism of anti-fibrotic effect of bone morphogenetic protein-7 remains unclear. Further studies are of great significance and may provide new therapeutic strategies for organ fibrosis.

Key words: bone morphogenic protein-7, organ fibrosis, mesenchymal to epithelial transition, epithelial to mesenchymal transition