Abstract:

Objective To investigate the incidence of Ureaplasma urealyticum (Uu) infection in genitourinary tract and mid-stream urine, and analyse its sensitivity to drugs. Methods Three thousand three hundred and twenty-six urine samples of genitourinary tract and 701 mid-stream urine samples were collected. Culture of mycoplasma (Uu+Mycoplasma humenis) and drug sensitivity tests were performed, and quantity of mycoplasma ≥104 CFU was regarded as positive. Results Among the 701 mid-stream urine samples, 130 （18.5%）samples were positive for Uu, including 124 females (124/650, 19.1%) and 6 males (6/51, 11.8%), and all were negative for Mycoplasma humenis. Among the 3 326 urine samples of genitourinary tract, 851 （25.6%）samples were positive for Uu, including 783 females (783/2 790, 28.1%) and 67 males (67/536, 12.5%), and 3 samples were positive for Mycoplasma humenis. Drug sensitivity tests of Uu in mid-stream urine revealed that drugs with highest sensitivity were josamycin (98.5%), doxycycline (97.9%) and pristinamycin (97.7%). Uu infection in midstream urine was more sensitive to josamycin, doxycycline and pristinamycin with lower resistance than genital secretion (P<0.05). The sensitivity of Un to azithromycin was only 70.2% in urinary tract infection, and that was 77.7% in genital tract infection, which was significantly lower than that to josamycin (98.5%). Conclusion The positive detection rate of Uu infection is relatively higher in initial screening of urinary infection. The sensitivity and resistance to antibiotics may be different in different sites of Uu infection. Josamycin and doxycycline may serve as the first-line therapy for urinary Uu infection.

Key words: Ureaplasma urealyticum, urinary tract infection, drug sensitivity test