›› 2013, Vol. 33 ›› Issue (1): 118-.doi: 10.3969/j.issn.1674-8115.2013.01.024

• Brief original article • Previous Articles     Next Articles

Diagnostic significance of expression of CK7 and S100A1 in chromophobe renal cell carcinoma and renal oncocytoma

XUAN Bei-lei, CHEN Yi-ming, LIU Qiang   

  1. Department of Pathology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200001, China
  • Online:2013-01-28 Published:2013-02-06

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Abstract:

Objective To investigate the expression and diagnostic significance of CK7 and S100A1 in chromophobe renal cell carcinoma (chRCC) and renal oncocytoma. Methods The expression of CK7 and S100A1 in 22 cases of chRCC and 20 cases of renal oncocytoma was determined by immunohistochemical staining. Results Positive expression of CK7 was observed in 20 cases (90.9%) of chRCC and 2 cases (10.0%) of renal oncocytoma (P=0.000). Positive expression of S100A1 was observed in 14 cases (63.6%) of chRCC and 19 cases (95.0%) of renal oncocytoma (P=0.003). Conclusion Immunohistochemical staining of CK7 and S100A1 may be helpful for differential diagnosis of chRCC and renal oncocytoma.

Key words: chromophobe renal cell carcinoma, renal oncocytoma, cytokeratin 7, S100A1