›› 2013, Vol. 33 ›› Issue (2): 181-.doi: 10.3969/j.issn.1674-8115.2013.02.011

• Original article (Clinical research) • Previous Articles     Next Articles

Analysis of relationship between clinical manifestations and karyotypes in 122 patients with hypospadias

LV Yong-fen, LI Pin, ZHU Zhi-ying, HUANG Ying-ying   

  1. Department of Endocrinology, Shanghai Children´s Hospital, Shanghai Jiaotong University Affiliated Children´s Hospital, Shanghai 200040, China
  • Online:2013-02-28 Published:2013-03-07
  • Supported by:

    Shanghai Municipal Health Bureau Foundation, 20114028


Objective To investigate the occurrence of other urinogenital system malformations in 122 patients with hypospadias, and analyse its relationship with karyotypes. Methods The clinical data of 122 patients with hypospadias were collected. The occurrence of other urinogenital system malformations was observed in patients with different types and severity of hypospadias. The karyotypes of 73 patients were analysed, and the types of hypospadias and occurrence of other urinogenital system malformations were observed in patients with abnormal chromosome. Results Among the 122 patients with hypospadias, 76 (62.3%) combined with other urinogenital system malformations, including penoscrotal transposition, hydrocele, cryptorchidism, indirect inguinal hernia and multiple deformity. Thirty-nine patients (32.0%) exhibited mild hypospadias, 38 (31.3%) moderate, 35 (28.7%) severe, and 10 (8.2%) had extremely severe hypospadias. The prevalences of other urinogenital system malformations in patients with moderate, severe, and extremely severe hypospadias were 73.7%, 68.6% and 70.0% respectively, all of which were significantly higher than that in patients with mild hypospadias (43.6%)(P<0.05). Four (5.5%) of the 73 patients undergoing karyotype analysis had abnormal chromosome. Conclusion The most common associated anomalies in patients with hypospadias is penoscrotal transposition, and the incidence of other urogenital system malformations is relatively higher in patients with moderate or more severe hypospadias. Abnormal karyotype is not the main factor of hypospadias combined with other malformations.

Key words: hypospadias, urogenital system, malformation, karyotype