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Application of thrombomodulin in treatment of sepsis

  • LU Hua-xiang ,
  • JIA Yi-tao ,
  • YAO Min ,
  • et al
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  • Department of Burns and Plastic Surgery, the Third People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201900, China

Online published: 2013-08-22

Abstract

Sepsis is a clinical syndrome which results from severe infection and systemic inflammatory response. Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. Thrombomodulin is an endogenous anticoagulant protein that possesses both anti-inflammatory and anticoagulant properties in directly and indirectly ways, which provides a new choice for the treatment of sepsis. The structure, function and application of thrombomodulin in the treatment of sepsis are introduced in this paper.

Cite this article

LU Hua-xiang , JIA Yi-tao , YAO Min , et al . Application of thrombomodulin in treatment of sepsis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2013 , 33(7) : 1039 . DOI: 10.3969/j.issn.1674-8115.2013.07.030

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