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Application of thrombomodulin in treatment of sepsis

LU Hua-xiang, JIA Yi-tao, YAO Min, FANG Yong   

  1. Department of Burns and Plastic Surgery, the Third People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 201900, China
  • Online:2013-07-28 Published:2013-08-22


Sepsis is a clinical syndrome which results from severe infection and systemic inflammatory response. Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. Thrombomodulin is an endogenous anticoagulant protein that possesses both anti-inflammatory and anticoagulant properties in directly and indirectly ways, which provides a new choice for the treatment of sepsis. The structure, function and application of thrombomodulin in the treatment of sepsis are introduced in this paper.

Key words: thrombomodulin, sepsis, anti-inflammation, anti-coagulation