Chemokine (C-C motif) ligand 7 (CCL7) is widely expressed in fibroblasts, monocytes and tumor cells, and exerts a spectrum of functions as monocyte recruitment, elicitation of calcium influx and facilitation of tumor metastasis via its interaction with specific receptors of CCR1, CCR2 and CCR3. This review will represent the up-to-date findings of CCL7 on its genetic and molecular structure, physiologic function, and its correlation with diseases.