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Research progress of CCL7

HU Qing-xiang1, QI Wen-xiao1, ZHANG Xue-fei1, ZHU Jia-fang1, JIN Ze-yu1, CHENG Feng2   

  1. 1.School of Clinical Medicine, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; 2.Experiment Teaching Center, Basic Medical College,
    Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2013-07-28 Published:2013-08-22
  • Supported by:

    Shanghai College Student Innovation Research Program, 2012020


Chemokine (C-C motif) ligand 7 (CCL7) is widely expressed in fibroblasts, monocytes and tumor cells, and exerts a spectrum of functions as monocyte recruitment, elicitation of calcium influx and facilitation of tumor metastasis via its interaction with specific receptors of CCR1, CCR2 and CCR3. This review will represent the up-to-date findings of CCL7 on its genetic and molecular structure, physiologic function, and its correlation with diseases.

Key words: chemokine (C-C motif) ligand 7, gene, molecular structure, tumor