JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (5): 678-683.doi: 10.3969/j.issn.1674-8115.2021.05.020

• Review • Previous Articles     Next Articles

Research progress of osteosarcopenia

Miao-miao CAI(), Yan-hong GAO()   

  1. Department of Geriatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2021-05-28 Published:2021-05-27
  • Contact: Yan-hong GAO;
  • Supported by:
    National Natural Science Foundation of China(81101360);Medical Guidance Project of Science and Technology Commission of Shanghai Municipality(18411964500)


Osreosarcopenia is a geriatric syndrome that describes the co-existence of osteoporosis and sarcopenia, which is widespread in the elderly. Osteoporosis is a condition of low bone mass and micro-architectural of bone, and sarcopenia, the loss of muscle mass, strength and muscle physiological functions. Sarcopenia and osteoporosis are age-related degenerative diseases with similar pathophysiology, including mechanical factors, genetics, fatty infiltration and endocrine factors. Studying the pathogenesis of sarcopenia-osteoporosis is of great significance in preventing and treating the disease, improving the quality of life and physical and mental health of the elderly. This review introduces the diagnosis, pathogenesis, intervention and treatment of osteosarcopenia.

Key words: osteosarcopenia, sarcopenia, osteoporosis, pathogenesis, therapeutic

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