›› 2019, Vol. 39 ›› Issue (9): 1095-.doi: 10.3969/j.issn.1674-8115.2019.09.025

• Review • Previous Articles     Next Articles

Advances of pathogenesis and clinical research in anti-N-methyl-D-aspartate receptor encephalitis

NI You, CHEN Sheng   

  1. Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2019-09-28 Published:2019-11-02
  • Supported by:
    National Natural Science Foundation of China, 81671241; Shanghai Shuguang Scholar Project, 18SG15; Shanghai Municipal Education Commission— Gaofeng Clinical Medicine Support, 20181802)。

Abstract: Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is one kind of autoimmune encephalitis that is mediatedNMDAR antibodies. Most of the patients are young women and some of them may suffer tumors. Diagnosis is mainly based on identification of NMDAR antibodies in cerebrospinal fluid and serum. Most patients can recover after removal of the tumor or through immunotherapy. This article reviews some viewpoints of pathogenesis, genetic features, clinical characteristics, treatment and prognosis of the disease.

Key words: anti-N-methyl-D-aspartate receptor encephalitis, autoimmune encephalitis, pathogenesis, clinical feature, gene

CLC Number: