JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (5): 659-664.doi: 10.3969/j.issn.1674-8115.2021.05.017

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Mechanisms related to regulation of natural killer cell activity by exosomes derived from malignant tumor cells

Ting-wei LU(), Jian-jun ZHANG, Wan-tao CHEN()   

  1. Department of Oral and Maxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai 200011, China
  • Online:2021-05-28 Published:2021-05-27
  • Contact: Wan-tao CHEN;
  • Supported by:
    National Natural Science Foundation of China(81874126);Project of Science?and?Technology?Commission?of?Shanghai?Municipality(18JC1413700);Innovation Research Team of High-Level Local Universities in Shanghai(SSMU-ZLCX20180502)


Exosomes are a kind of extracellular vesicles that play the role of transmitting information among cells. Through transporting of substances to regulate the physiological and pathological functions of various cells, it can affect the progress of malignant tumors. Natural killer (NK) cell is an indispensable part of the human immune system, and is important in the development of cancers. In the tumor microenvironment, tumor-derived exosomes (TDEXs) can act on NK cells, adjusting their functions, and modifying the interaction between NK cells and other immune cells, resulting in the change of the immune response. In recent years, the research on the relationship between NK cells and tumor exosomes has become a hot topic. The effects of TDEXs from different cancers on the activities of NK cells are summarized in this paper.

Key words: malignant tumor, tumor-derived exosome, natural killer cell, activity

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