JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (3): 376-379.doi: 10.3969/j.issn.1674-8115.2021.03.016

• Review • Previous Articles     Next Articles

Research progress in cue-reactivity of addictive substance and its neural mechanism

Ping-yuan YANG(), Hai-feng JIANG, Min ZHAO()   

  1. Department of Substance Dependence and Addiction, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Received:2019-12-21 Online:2021-03-28 Published:2021-04-06
  • Contact: Min ZHAO;
  • Supported by:
    National Nature Science Foundation of China(81771436);Shanghai 'Top Priority' Key Discipline(2017ZZ02021);Program of Shanghai Academic Research Leader(17XD1403300);Shanghai Municipal Health System Excellent Talents Training Program(2017YQ013)


Cue-reactivity of addictive substance is a kind of evoked physiological, behavioural and neural responses when an individual is exposed to cues previously associated with addictive substance taking. Cue-reactivity is one of the main features of addiction. It can evoke craving and plays an important role in relapse. However, the neuromechanism is still unknown. The review summarizes recent research progress in the neuromechanism of cue-reactivity and the condition of clinical therapies based on cue-reactivity, which helps deeply understand the development of addiction and set effective clinical intervention strategy.

Key words: substance addiction, cue-reactivity (CR), conditioned reflex, electrophysiology, cerebral nerve circuit

CLC Number: