JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (3): 380-385.doi: 10.3969/j.issn.1674-8115.2021.03.017

• Review • Previous Articles     Next Articles

Research progress of hydroxychloroquine in reproductive immunology

Xi KOU(), Ai-min ZHAO()   

  1. Department of Obstetric and Gynecology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Received:2020-07-17 Online:2021-03-28 Published:2021-04-06
  • Contact: Ai-min ZHAO;
  • Supported by:
    National Natural Science Foundation of China(81671481)


Hydroxychloroquine (HCQ) is a kind of synthetic 4-aminoquinoline antimalarial drugs. In recent years, other pharmacological effects of HCQ, such as immunomodulatory, immunosuppression, anti-inflammation, vascular endothelium protection, anti-thrombus, improving metabolic syndrome, and anti-infection, have been gradually known. At present, HCQ is a first-line drug for systemic lupus erythematosus. And in many guidelines for the treatment of autoimmune diseases, HCQ is recommended during whole pregnancy and lactation. This review mainly expounds the mechanism and research progress of HCQ in reproductive immunology, including pregnancy complicated with autoimmune diseases, such as systemic lupus erythematosus, antiphospholipid syndrome and Sjogren's syndrome, as well as unexplained recurrent spontaneous abortion and recurrent implantation failure, and explores the safety and application prospect of HCQ in reproductive immunology.

Key words: hydroxychloroquine (HCQ), reproductive immunology, pregnancy, drug mechanism, safety

CLC Number: