Journal of Shanghai Jiao Tong University (Medical Science) ›› 2022, Vol. 42 ›› Issue (7): 898-903.doi: 10.3969/j.issn.1674-8115.2022.07.008

• Clinical research • Previous Articles    

Predictive value of fibroblast growth factor 19 subgroup in early pregnancy on gestational diabetes mellitus

GAO Fei1,2(), LU Yu2(), DONG Shuqin1,2, YANG Liu1,2, WU Shaohua3, WEI Jing3   

  1. 1.Graduate School, Dalian Medical University, Dalian 116000, China
    2.Department of Endocrinology, Taizhou People's Hospital, Jiangsu Province, Taizhou 225300, China
    3.Department of Obstetrics, Taizhou People's Hospital, Jiangsu Province, Taizhou 225300, China
  • Received:2022-05-04 Accepted:2022-06-27 Online:2022-07-28 Published:2022-09-04
  • Contact: LU Yu E-mail:2827344131@qq.com;luyu_666@126.com
  • Supported by:
    Jiangsu Province High Level Talent Project(WSN-336);Jiangsu Province Top Talent Project(LGY2020067);Taizhou Science and Technology Support Plan Project(TS201902)

Abstract: Objective

·To investigate the relationship between serum levels of fibroblast growth factor 19 subgroup (FGF19, 21 and 23) and the risk of gestational diabetes mellitus (GDM) in early pregnancy.

Methods

·The levels of fasting blood glucose (FPG), blood lipid, FGF19, FGF21 and FGF23 of women in the early pregnancy (8-12 weeks) who underwent obstetric examination in Taizhou People's Hospital from October 2019 to October 2020 were collected. According to the results of 75 g oral glucose tolerance test at 24-28 weeks of pregnancy, they were divided into GDM group and NGT group. The levels of FGF19, FGF21 and FGF23 were compared between the two groups, and their relationship with GDM were analyzed.

Results

·A total of 180 pregnant women were followed up, including 27 cases in the GDM group and 153 cases in the NGT group. Compared with the NGT group, FGF21 levels in the GDM group were significantly higher, while the levels of FGF19 and FGF23 were significantly lower (P<0.05, respectively). Correlation analysis showed that FPG was negatively correlated with FGF19 (r=-0.283, P<0.01), and positively correlated with LogFGF21 (r=0.160, P<0.05), and had no significant correlation with LogFGF23 (P>0.05). Single factor regression analysis showed that FGF19, FGF21, FGF23 and FPG were influencing factors of GDM (P<0.05, respectively). Multivariate Logistic regression analysis showed that FGF21 and FPG were risk factors for GDM (OR=1.196, P=0.000; OR=2.280, P=0.010). The areas under the ROC curve of FGF21, FPG and their combined prediction of GDM were 0.707, 0.646 and 0.847.

Conclusion

·The levels of FGF21 and FPG increase, while the levels of FGF19 and FGF23 decrease in GDM pregnancies in early pregnancy. FGF21 and FPG are risk factors of GDM. The FGF21- and FPG- combined prediction of GDM has greater diagnostic efficiency.

Key words: fibroblast growth factor 19, fibroblast growth factor 21, fibroblast growth factor 23, blood glucose, gestational diabetes mellitus, early pregnancy

CLC Number: