Review

Research progress of long non-coding RNAs and their role in regulation of angiogenesis

  • LIU Juan ,
  • WANG Yang ,
  • SHEN Xiao-li ,
  • et al
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  • 1.Department of Neurosurgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China; 2.Limbs Institute of Microsurgery, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200025, China; 3.Department of Neurosurgery, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200025, China

Online published: 2013-09-29

Supported by

National Natural Science Foundation of China, 81160154, 81272170

Abstract

Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcript RNAs with more than 200 nt in length, which are pervasively transcribed in the genome. Recent researches have demonstrated that lncRNAs affect many biological processes, including X-inactivation, genomic imprinting, chromatinmodifying, transcriptional activation, transcriptional interference and nuclear-cytoplasmic trafficking, which indicates lncRNAs are not transcriptional noise but functional as a regulater of the gene expression on the epigenetic, transcriptional and post-transcriptional levels. The research progress of lncRNAs functions and their role in the regulation of angiogenesis is reviewed in this paper.

Cite this article

LIU Juan , WANG Yang , SHEN Xiao-li , et al . Research progress of long non-coding RNAs and their role in regulation of angiogenesis[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2013 , 33(9) : 1301 . DOI: 10.3969/j.issn.1674-8115.2013.09.024

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