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Research progress of long non-coding RNAs and their role in regulation of angiogenesis

LIU Juan1, WANG Yang2, SHEN Xiao-li1, DENG Zhi-feng1,3   

  1. 1.Department of Neurosurgery, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, China; 2.Limbs Institute of Microsurgery, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200025, China; 3.Department of Neurosurgery, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2013-09-28 Published:2013-09-29
  • Supported by:

    National Natural Science Foundation of China, 81160154, 81272170


Long non-coding RNAs (lncRNAs) are a novel class of non-protein-coding transcript RNAs with more than 200 nt in length, which are pervasively transcribed in the genome. Recent researches have demonstrated that lncRNAs affect many biological processes, including X-inactivation, genomic imprinting, chromatinmodifying, transcriptional activation, transcriptional interference and nuclear-cytoplasmic trafficking, which indicates lncRNAs are not transcriptional noise but functional as a regulater of the gene expression on the epigenetic, transcriptional and post-transcriptional levels. The research progress of lncRNAs functions and their role in the regulation of angiogenesis is reviewed in this paper.

Key words: long non-coding RNAs, angiogenesis, aHIF, MEG3, sONE, tie-1AS