Journal of Shanghai Jiao Tong University (Medical Science) >

2014 , Vol. 34 >Issue 4: 431

DOI: https://doi.org/10.3969/j.issn.1674-8115.2014.04.006

Monographic report

Comparison of the clinical features of patients with early-onset and late-onset treatment-resistant depression

  • LIAO Li-wei ,
  • WU Zhi-guo ,
  • CAO Lan ,
  • et al
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  • Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China

Online published: 2014-05-13

Supported by

the“10th Five-year Plan” of National Key Technoloogy R&D program, 2004BA720A21-02; National High-tech R&D Program, 2006AA02Z430； the “12th Five-year Plan” of National Key Technologies R&D Program, 2012BAI01B04; National Key Clinical Disciplines at Shanghai Mental Health Center, OMA-MH, 2011-873; Medical
Guidance Project of Science and Technology Commission of Shanghai Municipality, 134119b0400

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Abstract

Objective To compare the clinical features of patients with early-onset and late-onset treatment-resistant depression. Methods Three hundred and seventy adult patients with treatment-resistant depression were divided into the early-onset group (n=193) and late-onset group (n=177) by the median method. The clinical features of two groups were compared and analyzed. Results Compared to the late-onset group, the proportions of male, introverts, and patients who completed nine-year voluntary education of early-onset group were higher (P<0.001) and the current episodes were longer, i.e. (17.32±25.94) months and (12.47±18.42) months, respectively (P=0.015). Compared to the early-onset group, the proportion of married patients, Hamilton depressive scale-17 items (HAMD-17) scores of depression level, and factor sleep disorder scores of late-onset group were all significantly increased (P<0.001), and the proportion of physical comorbidities was much higher (P=0.008). Conclusion The clinical features of patients with early-onset and late-onset treatment-resistant depression are different. The differences may be relevant to the potential pathophysiological mechanisms.

Key words： early-onset; late-onset; treatment-resistant depression; clinical features

Cite this article

LIAO Li-wei , WU Zhi-guo , CAO Lan , et al . Comparison of the clinical features of patients with early-onset and late-onset treatment-resistant depression[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2014 , 34(4) : 431 . DOI: 10.3969/j.issn.1674-8115.2014.04.006

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