Review

Advances of DAF-2/IGF-1 signaling pathway relevant to aging in Caenorhabditis elegans

  • MAO Yu-qin ,
  • HAN San-feng ,
  • WANG Li-shun
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  • Center for Molecular Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Online published: 2014-06-30

Abstract

Ageing is one of the key factors that cause many diseases. Up-to-date, most knowledge and information about the genetics of ageing in biology comes from the studies on Caenorhabditis elegans (C.elegans). The C.elegans plays an important role in the study of anti-ageing. The first aging regulation mechanism understood by the people is the DAF-2/IGF-1 signal pathway. This paper reviews the leading and promoting effects of C.elegans, which acts as a model organism, on the course of research of the DAF-2/IGF-1 signal pathways and provides helpful ideas and methods for anti-ageing studies.

Cite this article

MAO Yu-qin , HAN San-feng , WANG Li-shun . Advances of DAF-2/IGF-1 signaling pathway relevant to aging in Caenorhabditis elegans[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2014 , 34(6) : 929 . DOI: 10.3969/j.issn.1674-8115.2014.06.033

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