Review

Research progresses of TGF-β/Smads signaling pathway-related therapeutic strategies for pathological scar

  • LI Ming ,
  • FANG Yong
Expand
  • Department of Burn & Plastic Surgery, Shanghai Ninth People‘s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China

Online published: 2016-05-26

Abstract

Pathological scar is a common and frequent disorder that seriously affects physical and psychological health of patients. Studies found that transforming growth factor β (TGF-β) is the most potent profibrosis factor known so far. TGF-β/Smads signal pathway is closely associated with scarring and is highlighted with inhibiting the activity of protease and matrix enzyme, as well as promoting the formation of extracellular matrixes such as collagen, and further promotes the deposition of extracellular matrixes. This paper reviews studies on prevention and treatment of pathological scar via TGF-β/Smads signal pathway and investigates better therapeutic methods.

Cite this article

LI Ming , FANG Yong . Research progresses of TGF-β/Smads signaling pathway-related therapeutic strategies for pathological scar[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2016 , 36(4) : 594 . DOI: 10.3969/j.issn.1674-8115.2016.04.027

Outlines

/