Objective·To investigate the correlation between the polymorphism of locus rs8637 in CD147 gene and instability of carotid plaque. Methods·Four hundred and forty-two inpatients with cerebral infraction were assigned to the vulnerable plaque group (n=320) and the stable plaque group (n=122) according to the results of carotid B-mode ultrasonography. The polymorphism of locus rs8637 in CD147 gene was analyzed by polymerase chain reaction-the ligase detection reaction (PCR-LDR). Results·The frequencies of AG+GG genotype and G allele at locus rs8637 in the vulnerable plaque group were 94.38% and 73.42%. The differences between two groups were statistically significant (P<0.05). The differences in age, blood glucose, blood pressure, TC, TAG, LDL-C, and HDL-C between the two groups were not statistically significant. Conclusion·The polymorphism of locus rs8637 in CD147 gene may be associated with carotid vulnerable plaque and the G allele may be a genetic susceptible gene for carotid vulnerable plaque.