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Correlation between the polymorphism of CD147 gene and instability of carotid plaque

SHEN Chen-chen1， MA Fei-yue1*， Feng Yu-lan2， Sun Jia-lan3， FU Yi4   

  1. 1.Department of Neurology， Ruijin Hospital Luwan Branch， Shanghai Jiao Tong University School of Medicine， Shanghai 200020， China； 2.Department of Neurology， Minhang Hospital, Fudan University， Shanghai 201199， China； 3.Department of Neurology， Public Hospital of Shanghai Pudong District， Shanghai 200135， China； 4.Department of Neurology， Ruijin Hospital， Shanghai Jiao Tong University School of Medicine， Shanghai 200025， China
  • Online:2016-10-28 Published:2016-11-29

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Abstract:

Objective·To investigate the correlation between the polymorphism of locus rs8637 in CD147 gene and instability of carotid plaque. Methods·Four hundred and forty-two inpatients with cerebral infraction were assigned to the vulnerable plaque group (n=320) and the stable plaque group (n=122) according to the results of carotid B-mode ultrasonography. The polymorphism of locus rs8637 in CD147 gene was analyzed by polymerase chain reaction-the ligase detection reaction (PCR-LDR). Results·The frequencies of AG+GG genotype and G allele at locus rs8637 in the vulnerable plaque group were 94.38% and 73.42%. The differences between two groups were statistically significant (P<0.05). The differences in age, blood glucose, blood pressure, TC, TAG, LDL-C, and HDL-C between the two groups were not statistically significant. Conclusion·The polymorphism of locus rs8637 in CD147 gene may be associated with carotid vulnerable plaque and the G allele may be a genetic susceptible gene for carotid vulnerable plaque.

Key words: CD147, single nucleotide polymorphism, cerebral infarction, carotid plaque