›› 2017, Vol. 37 ›› Issue (7): 891-.doi: 10.3969/j.issn.1674-8115.2017.07.002

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Association study of CFH gene polymorphisms with schizophrenia in Chinese Han population

GENG Rui-jie, BAO Chen-xi, LU Yan-hua, CHENG Xiao-yan, ZHU Ming-huan, JIA Si, ZHAO Jing, ZHANG Chen, LÜ Qin-yu#, YI Zheng-hui#   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2017-07-28 Published:2017-08-25
  • Supported by:
    National Natural Science Foundation of China, 81671326; Key Project for “Precision Medicine Research” , National Key Research and Development Program of China, 2016YFC0906402; Scientific Research Program of Science and Technology Commission of Shanghai Municipality, 17411970000; Fundamental Research Fund for the Central Universities, 16JXRZ06;International Cooperation Project of Shanghai Mental Health Center, 2015-YJGJ-03

Abstract:  Objective · To investigate the correlation of single nucleotide polymorphism (SNP) of complement factor H (CFH) gene with schizophrenia in Chinese Han population.  Methods · The genotype, allele, and haplotype frequencies of 5 SNP loci (rs800292, rs1061170, rs10801555, rs10922096 and rs2019727) in CFH gene were compared between 418 patients with schizophrenia (case group) and 655 normal people (control group) by SNaPshot technique.  Results · All SNP loci were well genotyped in the subjects. Correlation analysis showed that rs1061170 locus allele frequency distribution difference between case group and control group was statistically significant (corrected P=0.045), while genotype and allele frequencies of other SNP loci were not significantly different (all corrected P>0.05). The frequency of haplotype C-A-T-A-A (rs800292-rs1061170-rs10801555-rs10922096-rs2019727) in case group was different from that in control group (corrected P=0.013).  Conclusion · The allele polymorphisms of rs1061170 and the haplotype C-AT-A-A of rs800292-rs1061170-rs10801555-rs10922096-rs2019727 may be associated with schizophrenia in Chinese Han population.

Key words: schizophrenia, complement factor H gene, single nucleotide polymorphism, transmission disequilibrium, haplotype